Special issue: Preclinical meta research

This collection of articles highlights all research relating to our special issue focussing on preclinical meta research.

Guest Editors: David Howells (University of Tasmania, Australia) and Kim Wever (Radboud University Medical Center, Netherlands).

BMJ Open Science encourages proposals for themed collections of articles or special issues devoted to important and emerging topics in preclinical science related to medicine. To submit a proposal please see our Call for Guest Editors for more information. 

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Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu
Mira van der Naald, Steven A J Chamuleau, Julia M L Menon, Wim de Leeuw, Judith de Haan, Dirk J Duncker, Kimberley Elaine Wever
doi: 10.1136/bmjos-2021-100259

What has preclinical systematic review ever done for us?
Ash Allanna Mark Russell, Brad A Sutherland, Lila M Landowski, Malcolm Macleod, David W Howells
doi: 10.1136/bmjos-2021-100219

Publication rate in preclinical research: a plea for preregistration
Mira van der Naald, Steven Wenker, Pieter A Doevendans, Kimberley E Wever, Steven A J Chamuleau
doi: 10.1136/bmjos-2020-100108

Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis 
Fiona J Ramage, Alexander S Clewlow, Lynda M Williams, Malcolm R Macleod, Rosamund F Langston
doi: 10.1136/bmjos-2020-100108

A protocol for the systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain 
Xue Ying Zhang, Jan Vollert, Emily S Sena, Andrew SC Rice, Nadia Soliman
doi: 10.1136/bmjos-2020-100135

Comparison of commonly used methods in random effects meta-analysis: application to preclinical data in drug discovery research 
Ezgi Tanriver-Ayder, Christel Faes, Tom van de Casteele, Sarah K McCann, Malcolm R Macleod
doi: 10.1136/bmjos-2020-100074

Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF) 
Zsanett Bahor, Jing Liao, Gillian Currie, Can Ayder, Malcolm Macleod, Sarah K McCann, Alexandra Bannach-Brown, Kimberley Wever, Nadia Soliman, Qianying Wang, Lee Doran-Constant, Laurie Young, Emily S Sena, Chris Sena
doi: 10.1136/bmjos-2020-100103

Combined meta-analysis of preclinical cell therapy studies shows overlapping effect modifiers for multiple diseases 
Peter-Paul Zwetsloot, Ana Antonic-Baker, Hendrik Gremmels, Kimberley Wever, Chris Sena, Sanne Jansen of Lorkeers, Steven Chamuleau, Joost Sluijter, David W Howells
doi: 10.1136/bmjos-2020-100061

Technological advances in preclinical meta-research
Alexandra Bannach-Brown, Kaitlyn Hair, Zsanett Bahor, Nadia Soliman, Malcolm Macleod, Jing Liao
doi: 10.1136/bmjos-2020-100131

Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research
Timo Sander, Joly Ghanawi, Emma Wilson, Sajjad Muhammad, Malcolm Macleod, Ulf Dietrich Kahlert
doi: 10.1136/bmjos-2021-100272