BMJ Open Science is an open access journal which uses open peer review, the Creative Commons Attribution (CC BY) licence and has an open data policy.  There is an Article Processing Charge (APC) to publish in the journal.

We publish all preclinical and translational research that is closely aligned to medicine. We are keen to receive articles in the areas of neuroscience, genetics, regenerative medicine and many more.

Article processing charges

BMJ Open Science is an open access journal and levies an Article Publishing Charge (APC) of 1,500 GBP (+ any applicable VAT). There are no submission, colour or page charges. APCs for Registered Reports led by PhD students are currently waived. 

No payment information is requested before an article is accepted, so the ability to pay cannot affect editorial decisions. Accepted articles will not be published until payment has been received. BMJ does not refund APCs once paid.

As one of the founding members of the HINARI Access to Research in Health Programme, we provide free access to all of our journals, and journals archive to local, not-for-profit institutions in low income countries. In addition, we appreciate that some authors do not have access to funding to cover publication costs and we offer waivers through our Open Access Waiver Fund. We will accept part payment where only limited funds are available, and we offer waivers to authors in exceptional circumstances, on request.

For more information on open access, funder compliance, discounts and waivers please refer to the BMJ Author Hub open access page.


As an open access journal, BMJ Open Science adheres to the Budapest Open Access Initiative definition of open access. Articles are published under an exclusive licence or non-exclusive licence for UK Crown employees or where BMJ has agreed CC BY applies. For US Federal Government officers or employees acting as part of their official duties, the terms are as stated in accordance with our licence terms. Authors or their employers retain copyright. Such open access articles can be reused under the terms of the relevant Creative Commons licence to facilitate reuse of the content, please refer to the BMJ Open Science Author Licence. More information on copyright and authors’ rights.

All articles published in BMJ Open Science are published with a Creative Commons Attribution licence (CC BY). This is the required licence of most major biomedical research funders. Authors will need to agree to one of our licences to publish during submission.

Open peer review

BMJ Open Science uses open peer review. This means that the reviewers will know who wrote the article and the reviewers’ identities will be disclosed to you when an editorial decision is made. We also publish the peer review comments alongside any article we publish under the same licence (CC BY).

For more information about reviewing for BMJ Open Science please see here.

Data sharing

We have a strict, forward-thinking open data policy. This means that the data underlying the findings in your article should be made publicly available no later than when the article is published.

In exceptional circumstances, where there are restrictions on the availability of data, the Editor may agree to publish an article without publicly available data so long as the location, availability, and reason for restriction of the data is made clear in the article. A request for an exception must be made at submission or by contacting our editorial office in advance if you think you cannot comply with our policy.

The journal follows the TOP (Transparency and Openness Promotion) guidelines and promotes the FAIR data principles.

Read more here.


BMJ Open Science mandates ORCID iDs for the submitting author at the time of article submission; co-authors and reviewers are strongly encouraged to also connect their ScholarOne accounts to ORCID. We strongly believe that the increased use and integration of ORCID iDs will be beneficial for the whole research community.

Please find more information about ORCID and BMJ’s policy on our Author Hub.

Improve your article before peer review

BMJ Open Science encourages a number of initiatives to help the work that we publish be reproducible.

Penelope pre-submission manuscript checking

Before submitting your manuscript, consider checking it with Penelope, an award-winning online tool that checks the completeness of scientific manuscripts and gives immediate feedback to authors. It has been customised to BMJ Open Science guidelines to help you prepare for submission.

Reporting guidelines

As part of our commitment to reproducibility, we encourage authors to upload relevant reporting checklists as files for editors. You can find appropriate checklists, such as ARRIVE, at the EQUATOR and MERIDIAN sites.

We particularly encourage compliance with the Landis 4 criteria: randomisation, blinding, sample size calculation, and inclusion/exclusion criteria (doi:10.1038/nature11556), where appropriate. We are keen to be transparent about any limitations of methods used and non-compliance will not necessarily determine the article’s outcome.

When submitting an article you will be asked about the following:


Please describe how samples/animals were allocated to experimental groups. If randomisation was not described please explain why this was not possible or was not appropriate.


Please describe whether investigators were blinded to group allocation during the experiment and/or analysis. If blinding was not performed please explain why it was not possible or was not appropriate.

Sample size calculation

Please describe how sample size was determined. If a sample size calculation was not performed please explain why it was not possible or was not appropriate.


Please describe any a priori inclusion/exclusion criteria and any data exclusions with reasons.

Article types & manuscript preparation

Please review the below article type specifications including the required article lengths, illustrations, table limits and reference counts. The word count excludes the title page, abstract, tables, acknowledgements, contributions, and references. Manuscripts should be as succinct as possible.

For further support when making your submission please refer to the resources available on the BMJ Author Hub. Here you can also find general formatting guidelines across BMJ and a formatting checklist.

Please make sure you also read our specific BMJ Open Science editorial policies page, where you will find information on open data, materials and methods; formatting; author credit; and research ethics.

If your article is accepted you can take advantage of BMJ’s partnership with Kudos, a free service to help you maximise your article’s reach.


At BMJ Open Science, we divide our research articles into three types: confirmation studies, exploratory studies, and meta-research. This distinction values the differences in study designs, threats to validity, and the inferences specific to each research type. Further reading about how we came to these article types is in Kimmelman et al, 2014, PLOS Biology (doi:10.1371/journal.pbio.1001863) and Mogil et al, 2017, Nature (doi:10.1038/542409a). Each article type is described in full below.

All research articles must have a clear and justified research question and follow an IMRAD format (Introduction, Methods, Results and Discussion).

Please include in your article:

  • Title page: include authors and affiliations including ORCID identifiers.
  • A structured abstract (max. 250 words) including objectives, methods, results and conclusions
  • A separate ‘Strengths and limitations of the study’ section, containing up to 5 bullet points briefly stating the methodological strengths and limitations of the study paying particular attention to the Landis 4 criteria.
  • Introduction: a clear statement of the main study aims and major hypothesis/research question
  • Methods: details of the design, the subjects included, the Research Resource Identifiers (RRIDs) for critical reagents and tools, the main methods employed, and clearly defined primary/secondary outcomes (where appropriate). Please also include your DOIs if appropriate.
  • Results: the main findings with 95% confidence intervals, if appropriate.
  • Conclusions: primary conclusions and implications. Do not go beyond the data.
  • Full references
  • Data availability statement
  • Authors’ contributions as per the CRediT taxonomy.
  • Funding statement
  • Competing interests statement

Confirmation studies 

Confirmation studies are hypothesis-testing preclinical research studies. In addition to a clear and justified research question, confirmatory studies should be conducted and reported to the highest level of rigour.

Confirmatory primary research studies have two features:

    • The study must have been pre-registered in a protocol format, a registered report (see below for further details) or in a registry. This must be publicly available.
    • They must adhere to the highest levels of rigour in design, analysis and reporting. Where
      appropriate, studies must be randomised, blinded, state how they decided the number of animals included to ensure power, and describe exclusions. We encourage authors to refer to the Experimental Design Assistant for guidance with experimental design. Reporting must comply with the appropriate reporting guidelines for the study type (e.g. you may use ARRIVE guidelines for in vivo studies).

Exploratory studies

Exploratory studies (hypothesis-generating) are exploratory investigations that seek to generate robust pathophysiological theories of disease or intervention efficacy. These studies may be published alongside confirmation studies but must clearly be delineated as exploratory or submitted as stand-alone studies. The design, analysis and reporting of these studies will be held to the same high standard as confirmation studies but typically are not pre-registered, are not required to present a priori power calculations and do not necessarily use well-established techniques. Where no a priori power calculations have been provided, inferential statistics (e.g. p-values) are not appropriate and should not be presented; however, descriptive statistics (e.g. averages ± variances/confidence intervals) are appropriate and encouraged.


Meta-research studies investigate research itself and provide an evidence base for improvement and/or decision-making, including systematic reviews. They must address research questions relevant to preclinical research. We require pre-registration (e.g. via PROSPERO, OSF) or publication of a protocol prior to submission of the final article. Pre-registration or protocols must be publicly available and completed before completion of data collection.

BMJ Open Science will consider other types of primary research that is directly relevant to the design, conduct, reporting, or publishing of preclinical research.

Registered reports

Registered reports are a form of empirical article in which the methods and proposed analyses are pre-registered and reviewed prior to research being conducted. Data collection must not have begun. See here for more details.

Study protocols

BMJ Open Science will consider protocols for any study design, including observational studies and systematic reviews. Protocol manuscripts should report planned or ongoing research studies. If data collection is complete, we will not consider the manuscript. For protocols of preclinical systematic reviews, we encourage reference to de Vries et al. (2015). We strongly encourage you to register your protocol. We recommend the Open Science Framework, or Prospero for systematic reviews. Protocols for studies that require ethical approval, such as some in vivo studies, will not be considered without having received that approval.

Reviewers will be instructed to review for clarity and sufficient detail. The intention of peer review is not to alter the study design. Reviewers will be instructed to check that the study is scientifically credible and ethically sound in its scope and methods, and that there is sufficient detail to instil confidence that the study will be conducted and analysed appropriately.

  • Title: should include the word “protocol” or clearly reflect that the article is reporting a protocol.
  • Abstract: this should be structured with the following sections. Introduction; Methods and analysis; Ethics and dissemination. Registration details should be included as a final section, if appropriate. Abstracts for meta-research should be structured as follows: Objective (explain why you are doing the research); Search strategy (types of study to be included and which sources will be searched); Screening and annotation; Data management and reporting.
  • A separate ‘Strengths and limitations of the study’ section

Methods papers

BMJ Open Science will consider primary research studies that describe novel methods or significant improvement in standard research techniques of preclinical research close to medicine. Methods papers should provide researchers with new tools required to improve the validity of their research. Methods papers have the same IMRAD format, and the design, analysis and reporting of these studies will be held to the same high standard as original research articles. Step-by-step protocols required to allow replication of the methods must be deposited in a public and permanently available community-recognised repository (e.g. Dryad, Figshare).

Data descriptor articles

BMJ Open Science will consider data descriptor articles of preclinical studies or studies relevant to preclinical research. These articles should describe scientific data to facilitate data-sharing and reuse; their focus is to enable others to reuse data rather than presenting new hypotheses, analyses or interpretations. Descriptor articles combine traditional narrative content with curated structured metadata. Data descriptor articles should include detailed descriptions of the methods used to collect the data and technical analyses to support the quality of data acquisition. Peer review evaluates the rigour with which experiments were conducted during data acquisition. Data must be stored in public and permanently available community-recognised repositories (e.g. Dryad, Figshare).

  • Data descriptor articles should include the following:
  • Title page: include authors and affiliations
  • Abstract (max. 250 words)
  • A separate ‘Strengths and limitations of the study’ section, containing up to 5 bullet points briefly stating the methodological strengths and limitations of the study
  • Introduction and summary
  • Methods: details of the design, the subjects included, the main methods employed and any inclusion/exclusion criteria
  • Data records
  • Technical validation: include descriptive statistics
  • Usage notes: describe any code or software required for data reuse
  • Full references
  • Authors’ contributions
  • Funding statement
  • Competing interests statement

Reporting & conduct guidelines

Reporting and conduct guidelines within scope will be considered. We encourage reporting guidelines to be developed in accordance with Moher et al. (2010).

Review articles and position papers

These articles are usually commissioned or invited; however, authors are invited to discuss possible topics for submission directly with the Editor.

Plagiarism detection

BMJ is a member of CrossCheck by CrossRef and iThenticate. iThenticate is a plagiarism screening service that verifies the originality of content submitted before publication. iThenticate checks submissions against millions of published research papers, and billions of web content. Authors, researchers and freelancers can also use iThenticate to screen their work before submission by visiting