Table 8

95% CIs for the observed compliance (columns 1–4) and change in compliance (columns 5 and 6)

Item95% CI for compliance95% CI for change in compliance
NPG beforeNPG afterNon-NPG beforeNon-NPG afterNPGNon-NPG
In vivo: full Landis11.7 to 22.20.0 to 4.20.0 to 3.711.1 to 21.6−1.6 to 1.5
In vitro: full Landis1.5 to 7.10 to 4.20.7 to 5.9−0.6 to 1.8
In vivo: randomisation6.3 to 15.560.9 to 74.83.0 to 11.57.2 to 17.749.1 to 65.7−1.3 to 12.3
In vivo: blinding3.1 to 9.855.3 to 69.20.6 to 5.63.3 to 10.448.7 to 64.0−0.2 to 8.6
In vivo: exclusions reported9.7 to 19.324.5 to 37.66.1 to 15.310.1 to 20.08.6 to 24.8−2.3 to 11.3
In vivo: sample size calculation1.7 to 7.357.1 to 70.90.0 to 4.41.8 to 7.752.7 to 67.6−0.3 to 7.0
In vitro: randomisation12.9 to 24.40.1 to 5.512.3 to 24.3−4.4 to 1.8
In vitro: blinding2.2 to 9.217.2 to 29.60.7 to 6.92.0 to 8.511.2 to 25.5−2.8 to 6.4
In vitro: exclusions reported4.8 to 13.611.3 to 22.02.5 to 10.64.6 to 12.90.1 to 14.6−3.6 to 8.2
In vitro: sample size calculation2.2 to 9.227.8 to 41.82.0 to 8.522.0 to 37.60.6 to 8.4
In vivo: exact n39.8 to 52.762.4 to 75.538.8 to 54.040.1 to 54.213.8 to 32.6−9.6 to 11.0
In vivo: technical or biological replicates61.4 to 74.274.0 to 85.448.4 to 63.547.1 to 61.23.4 to 20.6−12.1 to 8.5
In vivo: number of times replicated17.3 to 28.930.5 to 44.415.7 to 28.314.1 to 25.45.4 to 23.5−10.7 to 6.2
In vivo: test described if uncommon?37.5 to 64.348.3 to 71.741.1 to 71.942.4 to 69.9−8.4 to 26.4−19.7 to 18.9
In vivo: t-test defined as one-sided or two-sided?37.6 to 54.462.9 to 77.721.8 to 39.736.8 to 55.313.4 to 35.62.7 to 28.2
In vivo: correction for multiplicity45.2 to 63.147.6 to 65.146.6 to 65.853.7 to 71.0−10.2 to 14.6−6.6 to 19.0
In vivo: reporting full statistics17.6 to 30.415.6 to 27.810.3 to 22.58.4 to 19.0−6.6 to 10.6−10.9 to 5.4
In vivo: reporting of average67.7 to 80.479.1 to 90.467.2 to 81.264.8 to 78.33.0 to 19.5−12.4 to 7.0
In vivo: definition of error bars82.2 to 91.987.1 to 95.474.8 to 87.471.2 to 83.8−0.12 to 10.8−12.5 to 5.3
In vivo: testing of assumptions5.4 to 14.020.5 to 33.95.2 to 15.17.4 to 17.69.8 to 25.9−4.7 to 9.6
In vivo: reporting measures of variation71.6 to 83.574.2 to 86.073.4 to 86.966.6 to 80.3−5.8 to 11.0−16.1 to 2.4
In vivo: variation less than twofold14.8 to 37.825.1 to 48.814.5 to 38.422.3 to 48.0−5.4 to 27.3−8.3 to 26.5
In vitro: exact n25.4 to 40.044.1 to 58.629.1 to 45.419.9 to 33.38.6 to 29.0−21.2 to −0.2
In vitro: technical or biological replicates48.8 to 64.168.5 to 81.031.2 to 47.635.1 to 50.18.6 to 28.3−7.9 to 14.3
In vitro: number of times replicated31.9 to 47.139.8 to 54.228.6 to 44.928.4 to 43.0−2.8 to 18.0−11.9 to 9.8
In vitro: test described if uncommon?39.7 to 69.049.0 to 73.629.5 to 58.022.6 to 51.9−11.7 to 26.0−26.9 to 13.4
In vitro: t-test defined as one-sided or two-sided?37.6 to 56.264.0 to 79.323.6 to 43.824.7 to 44.113.1 to 37.0−13.2 to 14.6
In vitro: correction for multiplicity37.6 to 56.742.6 to 60.836.7 to 57.644.2 to 63.5−8.5 to 17.7−7.4 to 20.9
In vitro: reporting full statistics12.4 to 25.111.8 to 23.58.9 to 22.09.2 to 21.0−9.7 to 7.6−9.3 to 8.5
In vitro: reporting of average74.5 to 87.381.4 to 91.862.9 to 78.667.4 to 81.3−2.4 to 13.8−6.8 to 14.1
In vitro: definition of error bars85.6 to 94.989.8 to 97.172.3 to 86.474.4 to 87.0−2.6 to 9.4−8.2 to 10.8
In vitro: testing of assumptions5.5 to 15.416.1 to 29.13.1 to 12.83.6 to 12.54.2 to 20.7−6.6 to 6.9
In vitro: reporting measures of variation67.6 to 81.474.8 to 86.762.7 to 78.462.1 to 76.9−2.8 to 15.5−11.8 to 9.7
In vitro: variation less than twofold9.8 to 31.717.2 to 40.415.4 to 40.524.9 to 52.6−7.5 to 24.3−7.3 to 30.0
Animals: was the species reported?97.7 to 10097.5 to 10095.8 to 99.996.3 to 99.9−2.0 to 1.9−2.4 to 2.9
Animals: was the strain reported?87.5 to 95.191.8 to 97.985.4 to 94.488.5 to 96.0−1.2 to 8.6−3.5 to 8.4
Animals: was the sex reported?29.3 to 47.845.0 to 59.329.6 to 44.430.0 to 43.86.4 to 26.0−10.2 to 10.0
Animals: was exact age or weight given?11.0 to 20.916.5 to 28.319.0 to 32.215.4 to 27.0−1.2 to 14.3−13.2 to 4.4
Animals: was ethical approval reported?52.7 to 66.560.1 to 74.452.3 to 67.861.2 to 74.7−1.6 to 17.7−2.2 to 18.3
Animals: ethical guidelines reported?67.9 to 80.079.1 to 89.665.9 to 79.968.9 to 81.42.6 to 18.6−7.1 to 11.6
Reagents: in vivo antibodies54.4 to 70.264.5 to 79.425.1 to 42.137.2 to 54.4−1.1 to 20.60.2 to 24.4
Reagents: in vitro antibodies51.2 to 68.267.6 to 81.720.1 to 37.232.2 to 49.24.1 to 26.20.2 to 24.2
Reagents: total antibodies55.4 to 67.168.5 to 78.824.8 to 37.037.1 to 49.34.7 to 20.23.8 to 20.9
Cell line: source40.4 to 59.661.9 to 77.152.3 to 72.746.5 to 64.87.6 to 31.9−20.5 to 6.7
Cell line: recent authentication?0.2 to 7.13.8 to 13.22.0 to 13.20.2 to 7.00.3 to 12.0−11.8 to 1.4
Cell line: recent mycoplasma testing?0.2 to 7.019.1 to 34.30.2 to 8.60.2 to 7.016.7 to 33.2−6.0 to 4.4
Accession: DNA/protein36.9 to 61.538.0 to 62.027.8 to 68.228.8 to 56.9−16.2 to 17.8−29.4 to 18.7
Accession: macromolecular0.0 to 60.420.2 to 88.20.0 to 80.221.9 to 98.7−1.4 to 84.1−4.6 to 95.4
Accession: crystallography30.2 to 94.97.3 to 60.79.4 to 90.50.0 to 94.5−71.0 to 1.9−39.1 to 90.6
Accession: microarray21.9 to 53.739.5 to 70.124.1 to 70.742.9 to 84.2−4.2 to 39.2−12.6 to 47.7
Accession: other7.2 to 67.324.0 to 67.010.5 to 70.124.1 to 94.0−24.8 to 45.7−9.4 to 75.4
Computer code: with paper?7.1 to 49.49.0 to 41.30.0 to 53.73.6 to 42.7−29.2 to 23.4−30.4 to 39.9
Computer code: in public domain?9.0 to 58.69.0 to 41.30.0 to 53.73.9 to 45.1−37.9 to 19.9−29.4 to 42.2
Computer code: was that code accessible?12.5 to 98.230.2 to 94.90.0 to 94.515.0 to 85.0−40.0 to 55.0−36.7 to 85.0
Computer code: did the code function ?12.5 to 98.219.8 to 100−37.8 to 79.2
Computer code: say where you could get code?0.0 to 37.10.3 to 32.37.2 to 83.00.0 to 34.4−24.1 to 28.3−76.9 to −0.4
Human materials reporting ethical approvals67.0 to 90.469.9 to 90.136.3 to 74.860.4 to 87.2−14.2 to 16.8−3.9 to 42.2
Human materials reporting consent69.0 to 91.871.9 to 91.442.2 to 79.247.0 to 76.8−13.8 to 16.4−22.1 to 24.6
Human materials consent to photos12.5 to 98.25.4 to 1000.0 to 80.2−50.5 to 79.2
Human materials clinical trial number12.5 to 98.25.4 to 100
Human materials CONSORT0.0 to 94.5
Human materials REMARK0.0 to 94.50.0 to 80.20.0 to 94.5−65.8 to 79.4
  • Colours represent CIs falling below (red), encompassing (yellow) and exceeding (green) 80% compliance (1–4) or a 15% improvement in compliance. Deeper colours relate to the editorially important change criteria identified in the study protocol. Grey boxes: not applicable.

  • CONSORT, Consolidated Standards of Reporting Trials; NPG, Nature Publishing Group.