Table 3

Primary outcome: compliance with Landis 4 guidelines, in vivo research

ItemNPG beforeNPG afterNon-NPG beforeNon-NPG after
nN%CInN%CIpnN%CInN%CIp
In vivo
Full Landis020300.0 to 2.33118916.411.6 to 22.6<10−8 11640.60.1 to 4.211890.50.1 to 3.7NS
  • n, number meeting the criteria; N, total number of studies where that criteria is relevant; %, per cent meeting the criteria; CI, 95% CI of that percentage; p, significance level (two-sample proportion test); NS, not significant at p<0.05.

  • NPG, Nature Publishing Group.