Table 1

Characteristics of 20 randomly selected systematic reviews, including the disease or biological system of interest and the treatment/intervention being investigated. Total number of studies identified through systematic searches and number of studies included in each review’s final analysis were self-reported in each publication, percentage of studies included out of all studies identified was calculated by the authors of this paper

Study (reference)Disease/biological systemTreatment/intervention# studies identified from searches# studies included in final analysis% studies included in final analysis
Albuquerque et al12MelanomaPlant extracts1359352.6
Archambault et al13Neonatal hypoxic ischaemic encephalopathy (HIE)Mesenchymal stem/stromal cells (MSCs)1611811.2
Ashcraft et al14CancerAerobic exercise4665311.4
Auboire et al15Ischaemic strokeMicrobubbles (MBs) combined with ultrasound sonothrombolysis (STL)2506160.6
Cao et al16Gut microbiotaAnti-hyperglycaemic drugs4075641.6
Chen et al17Ischaemic strokeNeural stem cells (NSCs) transplantation therapy2524371.5
Dong et al18Ischaemic strokeRecombinant tissue plasminogen activator (rtPA)2128472.2
Gaubys et al19Regeneration of periodontal tissue complexStem cell therapy2099100.5
Janssen20Ischaemic strokeConstraint-induced movement therapy (CIMT)358080.2
Lambrecht21AnaemiaAnimal husbandry and capture (AHC)9027230.3
Li et al22Hepatocellular carcinomaMetformin573132.3
Liao et al23Injury to boneStem cell therapy202209.9
Ma et al24Ischaemic strokeXingnaojing injection (XNJI)392235.9
Senders et al25Glioma surgeryAgents for fluorescence-guided glioma surgery26191054.0
Silverblatt et al26Myocardial injuryBeta blockers, calcium channel blockers and antagonists of the renin–angiotensin system3475215.0
Suen et al27Pulmonary arterial hypertension (PAH)Regenerative cell therapies1368453.3
van der Bent et al28Heritable neurodegenerative and neuromuscular diseasesAntisense oligonucleotide (AON)-based therapies1330957.1
van der Spoel et al29Ischaemic heart diseaseStem cell therapy3045217.1
Wei et al30Ischaemic strokeBuyang Huanwu decoction (BHD)973565.8
Zhang et al31Vascular dementiaAcupuncture194168.2