Table 2

Ovid MEDLINE search strategy: Ovid MEDLINE(R) and Epub Ahead of Print, In-Process, In-Data-Review and Other Non-Indexed Citations, Daily and Versions(R)

Search component
(number)
Search term typeSearch aliasSearch content
Pharmacological PPAR Targeting
(SC1)
Adapted with modifications from Liu and Wang60
Free-textMED_PPAR_FREE((‘peroxisome proliferator-activated receptor’ OR 'ppar') adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
((‘peroxisome proliferator-activated receptor alpha’ OR 'ppar alpha' OR ‘ppar-alpha’ OR ‘pparalpha’ OR ‘ppara’ OR ‘nr1c1’) adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
((‘peroxisome proliferator-activated receptor beta‘OR ‘'ppar beta’ OR ‘ppar-beta’ OR ‘pparbeta’ OR ‘pparb’ OR ‘peroxisome proliferator-activated receptor delta’ OR ‘ppar delta’ OR ‘ppar-delta’ OR ‘ppardelta’ OR ‘ppard’ OR ‘nr1c2’) adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
((‘peroxisome proliferator-activated receptor gamma’ OR ‘ppar gamma’ OR ‘ppar-gamma’ OR ‘ppargamma’ OR ‘pparg’ OR 'nr1c3') adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
((‘dual-PPAR’ OR ‘dual PPAR’ OR ‘PPAR-dual’ OR ‘PPAR dual’ OR ‘dual-peroxisome proliferator-activated receptor’ OR ‘dual peroxisome proliferator-activated receptor’ OR ‘peroxisome proliferator-activated receptor-dual’ OR ‘peroxisome proliferator-activated receptor dual’) adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
((‘pan-PPAR’ OR ‘pan PPAR’ OR ‘PPAR-pan’ OR ‘PPAR pan’ OR ‘pan-peroxisome proliferator-activated receptor’ OR ‘pan peroxisome proliferator-activated receptor’ OR ‘peroxisome proliferator-activated receptor-pan’ OR ‘peroxisome proliferator-activated receptor pan’) adj5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)).ti,ab,kw. OR
(‘fibrate’ OR ‘fibrates’ OR ‘fibric acid’ OR ‘fibric acids’ OR ‘fibric acid derivative’ OR ‘fibric acid derivatives’ OR ‘bezafibrate’ OR ‘bezafibric acid’ OR ‘ciprofibrate’ OR ‘ciprofibric acid’ OR ‘clinofibrate’ OR ‘aluminium clofibrate’ OR ‘aluminium clofibric acid’ OR ‘clofibrate’ OR ‘clofibric acid’ OR ‘clofibride’ OR ‘choline fenofibrate’ OR ‘choline fenofibric acid’ OR ‘fenofibrate’ OR ‘fenofibric acid’ OR ‘gemfibrozil’ OR ‘simfibrate’).ti,ab,kw. OR
(‘WY-14,643’ OR ‘WY-14643’ OR ‘WY 14,643’ OR ‘WY 14643’ OR ‘WY14,643‘OR ‘WY14643’ OR ‘pirinixic acid’).ti,ab,kw. OR
(‘selective peroxisome proliferator-activated receptor modulat*' OR ’selective PPAR modulat*’ OR ‘SPPAR’ OR ‘SPPARM’ OR ‘SPPARM alpha’ OR ‘SPPARM-alpha’ OR ‘SPPARMalpha’ OR ‘SPPARMa’ OR ‘pemafibrate’ OR ‘K-877’ OR ‘K877’).ti,ab,kw. OR
(‘thiazolidinedione’ OR ‘thiazolidinediones’ OR ‘glitazone’ OR ‘glitazones’ OR ‘pioglitazone’ OR ‘rosiglitazone’ OR ‘troglitazone’ OR ‘netoglitazone’ OR ‘rivoglitazone’ OR ‘ciglitazone’ OR ‘balaglitazone’ OR ‘darglitazone’ OR ‘edaglitazone’ OR ‘englitazone’ OR ‘lobeglitazone’).ti,ab,kw. OR
(‘glitazar’ OR ‘glitazars’ OR ‘ragaglitazar’ OR ‘tesaglitazar’ OR ‘muraglitazar’ OR ‘naveglitazar’ OR ‘aleglitazar’ OR ‘saroglitazar’).ti,ab,kw. OR
(‘lanifibranor’ OR ‘elafibranor’ OR ‘tetradecylthioacetic acid’).ti,ab,kw. OR
((‘fatty acid metabolism’ OR ‘fatty acid oxidation’) adj5 (pharmacol*)).ti,ab,kw.
StandardisedMED_PPAR_INDEXED(exp Peroxisome Proliferator-Activated Receptors/ OR exp Fibric Acids/ OR exp Thiazolidinediones/)
Free-text or standardisedMED_PPAR_COMBINEDMED_PPAR_FREE OR MED_PPAR_INDEXED
Kidney Disease
(SC2)
Adapted with modifications from Mihajlovic et al61 and from Hickson et al62
Free-textMED_KIDNEY_FREE(‘kidney disease’ OR ‘kidney injury’ OR ‘kidney ischemia’ OR ‘kidney ischaemia’ OR ‘kidney diseases’ OR ‘kidney failure’ OR ‘kidney insufficiency’ OR ‘kidney fibrosis’ OR ‘renal disease’ OR ‘renal diseases’ OR ‘renal injury’' OR ‘renal ischemia’ OR ‘renal ischaemia’ OR ‘renal failure’ OR ‘enal insufficiency’ OR ‘renal fibrosis’ OR ‘acute kidney injury’ OR ‘acute renal injury’ OR ‘chronic kidney disease’ OR ‘chronic renal disease’ OR ‘diabetic kidney disease’ OR ‘diabetic renal disease’ OR ‘diabetic nephropathy’ OR ‘nephropathy’).ti,ab,kw.
StandardisedMED_KIDNEY_INDEXED(exp kidney diseases/ OR exp acute kidney injury/ OR exp Kidney Failure, Chronic/ OR exp Renal Insufficiency/ OR exp Diabetic Nephropathies/)
Free-text or standardisedMED_KIDNEY_COMBINEDMED_KIDNEY_FREE OR MED_KIDNEY_INDEXED
Animal Models
(SC3)
Free-textMED_ANIMAL_FREESYRCLE MEDLINE via PubMed animal search filter63 adapted for MEDLINE via Ovid
StandardisedMED_ANIMAL_INDEXEDSYRCLE MEDLINE via PubMed animal search filter63 adapted for MEDLINE via Ovid
Free-text or standardisedMED_ANIMAL_COMBINEDMED_ANIMAL_FREE OR MED_ANIMAL_INDEXED
Final Search
(SC1 AND SC2 AND SC3)
PPAR, kidney disease and animal model search termsMED_FINALMED_PPAR_COMBINED AND MED_KIDNEY_COMBINED AND MED_ANIMAL_COMBINED
  • PPAR, peroxisome proliferator-activated receptor; SC, search component; SYRCLE, Systematic Review Centre for Laboratory Animal Experimentation.