Table 3

Embase via Embase.com search strategy

Search component
(number)
Search term typeSearch aliasSearch content
Pharmacological PPAR Targeting
(SC1)
Adapted with modifications from Liu and Wang60
Free-textEMB_PPAR_FREE((‘peroxisome proliferator-activated receptor’ OR ‘ppar’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
((‘peroxisome proliferator-activated receptor alpha’ OR ‘ppar alpha’ OR ‘ppar-alpha’ OR ‘pparalpha’ OR ‘ppara’ OR ‘nr1c1’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
((‘peroxisome proliferator-activated receptor beta’ OR ‘ppar beta’ OR ‘ppar-beta’ OR ‘pparbeta’ OR ‘pparb’ OR ‘peroxisome proliferator-activated receptor delta’ OR ‘ppar delta’ OR ‘ppar-delta’ OR ‘ppardelta’ OR ‘ppard’ OR ‘nr1c2’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
((‘peroxisome proliferator-activated receptor gamma’ OR ‘ppar gamma’ OR ‘ppar-gamma’ OR ‘ppargamma’ OR ‘pparg’ OR ‘nr1c3’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
((‘dual-PPAR’ OR ‘dual PPAR’ OR ‘PPAR-dual’ OR ‘PPAR dual’ OR ‘dual-peroxisome proliferator-activated receptor’ OR ‘dual peroxisome proliferator-activated receptor’ OR ‘peroxisome proliferator-activated receptor-dual’ OR ‘peroxisome proliferator-activated receptor dual’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
((‘pan-PPAR’ OR ‘pan PPAR' OR 'PPAR-pan’ OR ‘PPAR pan’ OR ‘pan-peroxisome proliferator-activated receptor’ OR ‘pan peroxisome proliferator-activated receptor’ OR ‘peroxisome proliferator-activated receptor-pan’ OR ‘peroxisome proliferator-activated receptor pan’) NEAR/5 (agonist* OR modulator* OR stimulat* OR stimulant* OR activat*)):ti,ab,kw OR
(‘fibrate’ OR ‘fibrates’ OR ‘fibric acid’ OR ‘fibric acids’ OR ‘fibric acid derivative’ OR ‘fibric acid derivatives’ OR ‘bezafibrate’ OR ‘bezafibric acid’ OR ‘ciprofibrate’ OR ‘ciprofibric acid’ OR ‘clinofibrate’ OR ‘aluminium clofibrate’ OR ‘aluminium clofibric acid’ OR ‘clofibrate’ OR ‘clofibric acid’ OR ‘clofibride’ OR ‘choline fenofibrate’ OR ‘choline fenofibric acid’ OR ‘fenofibrate’ OR ‘fenofibric acid’ OR ‘gemfibrozil’ OR ’simfibrate’):ti,ab,kw OR
(‘WY-14,643’ OR ‘WY-14643’ OR ‘WY 14,643’ OR ‘WY 14643’ OR ‘WY14,643’ OR ‘WY14643’ OR ‘pirinixic acid’):ti,ab,kw OR
(‘selective peroxisome proliferator-activated receptor modulat*’ OR ‘selective PPAR modulat*’ OR ‘SPPAR‘ OR ‘SPPARM’ OR ‘SPPARM alpha’ OR ‘SPPARM-alpha’ OR ‘SPPARMalpha’ OR ‘SPPARMa’ OR ‘pemafibrate’ OR 'K-877' OR 'K877'):ti,ab,kw OR
(‘thiazolidinedione’ OR ‘thiazolidinediones’ OR ‘glitazone’ OR ‘glitazones’ OR ‘pioglitazone’ OR ‘rosiglitazone’ OR ’troglitazone’ OR ’netoglitazone’ OR ’rivoglitazone’ OR ’ciglitazone’ OR ’balaglitazone’ OR ’darglitazone’ OR ‘edaglitazone’ OR ‘englitazone’ OR ‘lobeglitazone’):ti,ab,kw OR
(‘glitazar’ OR ‘glitazars’ OR ‘ragaglitazar’ OR ‘tesaglitazar’ OR ‘muraglitazar’ OR ‘naveglitazar’ OR ‘aleglitazar’ OR ‘saroglitazar’):ti,ab,kw OR
(‘lanifibranor’ OR ‘elafibranor’ OR ‘tetradecylthioacetic acid’):ti,ab,kw OR
((‘fatty acid metabolism’' OR ‘fatty acid oxidation’) NEAR/5 (pharmacol*)):ti,ab,kw
StandardisedEMB_PPAR_INDEXED(‘peroxisome proliferator activated receptor’/exp OR ‘peroxisome proliferator activated receptor agonist’/exp OR ‘peroxisome proliferator activated receptor alpha agonist’/exp OR ‘peroxisome proliferator activated receptor delta agonist’/exp OR ‘peroxisome proliferator activated receptor gamma agonist’/exp OR ‘'fibric acid derivative’/exp OR ‘glitazone derivative’/exp)
Free-text or standardisedEMB_PPAR_COMBINEDEMB_PPAR_FREE OR EMB_PPAR_INDEXED
Kidney Disease
(SC2)
Adapted with modifications from Mihajlovic et al61 and from Hickson et al62
Free-textEMB_KIDNEY_FREE(‘kidney disease’ OR ‘kidney injury’ OR ‘kidney ischemia’ OR ‘kidney ischaemia’ OR ‘kidney diseases’ OR ‘kidney failure’ OR ‘kidney insufficiency’ OR ‘kidney fibrosis’ OR ‘renal disease’ OR ‘renal diseases’ OR ‘renal injury’ OR ‘renal ischemia’ OR ‘renal ischaemia’ OR ‘renal failure’ OR ‘renal insufficiency’ OR ‘renal fibrosis’ OR ‘acute kidney injury’ OR ‘acute renal injury’ OR ‘chronic kidney disease’ OR ‘chronic renal disease’ OR ‘diabetic kidney disease’ OR ‘diabetic renal disease’ OR ‘diabetic nephropathy’ OR ‘nephropathy’):ti,ab,kw
StandardisedEMB_KIDNEY_INDEXED‘kidney injury’/exp OR ‘artificial kidney’/exp OR ‘kidney disease’/exp OR ‘kidney failure’/exp OR ‘diabetic nephropathy’/exp
Free-text or standardisedEMB_KIDNEY_COMBINEDEMB_KIDNEY_FREE OR EMB_KIDNEY_INDEXED
Animal Models
(SC3)
Free-textEMB_ANIMAL_FREESYRCLE EMBASE via Ovid animal search filter64 65 adapted for EMBASE via EMBASE.com
StandardisedEMB_ANIMAL_INDEXEDSYRCLE EMBASE via Ovid animal search filter64 65 adapted for EMBASE via EMBASE.com
Free-text or standardisedEMB_ANIMAL_COMBINEDEMB_ANIMAL_FREE OR EMB_ANIMAL_INDEXED
Final Search
(SC1 AND SC2 AND SC3)
PPAR, kidney disease and animal model search termsEMB_FINALEMB_PPAR_COMBINED AND EMB_KIDNEY_COMBINED AND EMB_ANIMAL_COMBINED AND (embase)/lim NOT ((embase)/lim AND (medline)/lim)
  • PPAR, peroxisome proliferator-activated receptor; SC, search component; SYRCLE, Systematic Review Centre for Laboratory Animal Experimentation.