Data extracted from each publication
Bibliographic information | Authorship, year, journal |
Experimental design | See items in the adapted CAMARADES checklist (box 1) and RoB Syrcle tool23 |
Population | Species, strain, sex, age, the timing of euthanasia, phenotype of experimental rodents |
Intervention | SR 1–3 (antidepressants): Type, mechanism of action, dose, via, number of injections per day. SR 3 (ablation of neurogenesis): the method employed to the ablation |
Comparison | SR 1, 2: Type of vehicle. SR 3: the method employed to the sham ablation. |
Outcome (qualitative) | SR 1, 2: Type of marker, antibodies used, the protocol for detection, protocols for BrdU injection (survival or proliferation), protocols of measuring (stereological or non-stereological). SR 2, 3: type, metrics and method of acquisition (manual or automatic) of the behavioural outcome. |
Outcome (quantitative) | All SRs (per outcome, for experimental and control groups): mean, SD or SE, sample size (when available, effect sizes with 95% CI), p values or the values of F or t, and correlation indexes (SR 2). |
RoB, risk of bias; SR, systematic review.