Table 5

Summary of the selected univariate meta-regression results based on different estimation techniques using each study characteristic variable as a moderator to explain the extra heterogeneity present in infarct volume data

MethodVariableEstimate
(SE/MC error)
95% ClP valueτ2I2 (%)R2 (%)
REMLNo covariate35.5 (2.35)30.8 to 40.2<0.0001213.982.40
Time to outcome measure (intercept)37.7 (2.75)32.3 to 43.2<0.0001206.480.803.50
Time to outcome measure−0.03 (0.02)−0.06 to 0.010.12
Route of drug delivery (intercept)31.5 (3.27)24.9 to 38.0<0.0001120.169.6043.90
Route of delivery (intracerebroventricular)20.3 (5.54)9.25 to 31.40.001
Route of drug delivery (other)−14.6 (5.67)−26.0 to −3.310.01
Route of drug delivery (intravenous)5.79 (4.99)−4.19 to 15.80.25
Dose (intercept)38.0 (2.91)32.2 to 43.8<0.0001221.981.700
Dose−0.02 (0.02)−0.05 to 0.010.17
DLNo covariate35.7 (2.35)31.0 to 40.4<0.0001235.283.70
Time to outcome measure (intercept)38.0 (2.75)32.5 to 43.5<0.0001253.383.800
Time to outcome measure−0.03 (0.02)−0.06 to 0.010.13
Route of drug delivery (intercept)32.4 (3.31)25.8 to 39.1<0.0001177.877.2024.40
Route of delivery (intracerebroventricular)19.3 (5.49)8.28 to 30.30.001
Route of drug delivery (other)−15.5 (5.99)−27.4 to −3.500.01
Route of drug delivery (intravenous)4.48 (5.02)−5.57 to 14.50.38
Dose (intercept)38.4 (2.91)32.5 to 44.2<0.0001263.584.200
Dose−0.02 (0.02)−0.05 to 0.010.15
BayesianNo covariate35.5 (0.03)30.3 to 40.7<0.0001224.2
Time to outcome measure (intercept)37.6 (0.05)31.7 to 37.6<0.0001215.2
Time to outcome measure−0.03 (0.0004)−0.07 to 0.010.14
Route of drug delivery (intercept)31.5 (0.10)24.4 to 39.3<0.0001127.7
Route of delivery (intracerebroventricular)20.2 (0.15)7.78 to 32.30.002
Route of drug delivery (other)−14.6 (0.12)−27.7 to −1.990.03
Route of drug delivery (intravenous)5.85 (0.13)−5.50 to 16.90.31
Dose (intercept)37.9 (0.06)31.7 to 44.7<0.0001232.9
Dose−0.02 (0.0003)−0.0 to 0.010.17
  • P values are calculated based on Wald-type test statistics and mako. Associated full tables can be found in the Appendix (https://osf.io/6usxq/) (Embedded Image, Embedded Image).

  • DL, DerSimonian and Laird; MC, Monte Carlo; REML, restricted maximum likelihood.