Table 3

Estimated overall effect sizes and corresponding CIs/credibility intervals for infarct volume (NMD), neurobehavioural score (NMD) and mortality data (log OR) using three different estimation methods for random effects meta-analysis of the effect of IL-1RA after stroke in animals

OutcomeMethodEstimate (95% CI)Q statisticEmbedded Image(95% CI)I2
Infarct volumeREML36.2 (32.1 to 40.3)423.4*187.5 (72.5 to 234.0)0.79
DL36.5 (32.4 to 40.6)423.4*236.9 (–)0.82
Bayesian36.5 (32.4 to 40.6)194.1 (113.6 to 314.2)
Neurobehavioural scoreREML36.5 (32.4 to 40.6)76.5*208.0 (47.4 to 407.5)0.59
DL35.9 (28.8 to 42.9)76.5*202.6 (–)0.58
Bayesian38.9 (31.2 to 46.5)317.7 (137.2 to 629.5)
MortalityREML0.03 (−0.51 to 0.58)2.870 (0.00 to 0.10)0
DL0.03 (−0.51 to 0.58)2.870 (–)0
Bayesian0.04 (−0.82 to 0.93)0.19 (0.001 to 1.38)
  • *Indicates significance with α=0.05.

  • DL, DerSimonian and Laird; IL-1RA, nterleukin-1 receptor antagonist; NMD, normalised mean difference; REML, restricted maximum likelihood.