Table 2

List of principal antibiotics used as monotherapy or in combination against carbapenem-resistant bacilli in clinical practice (already approved or in late stage of development)

ClassApprovedRecently* FDA approvedPhase 3 studies
AminoglycosideGentamicin; amikacin
tobramycin
Plazomicin
BLBLIAmpicillin–sulbactam
Piperacillin–tazobactam
Cefoperazone–sulbactam
Ceftadizime–avibactam
Meropenem–vaborbactam
Ceftolozane–tazobactam
Imipenem–relebactam
Aztreonam–avibactam
Ceftaroline–avibactam
Cefepime–taniborbactam
Cefepime–zidebactam
CarbapenemMeropenem; imipenem; doripenem; ertapenem
CephalosporinCefiderocol
Dihydrofolate reductase inhibitorIclaprim
FluoroquinoloneDelafloxacin
MonobactamAztreonam
Phosphonic acid derivativeFosfomycin
PolymyxinPolymyxin B
polymyxin E/colistin
RifamycinRifampicin
TetracyclineDoxycycline; tigecycline; minocyclineEravacycline
Omadacycline
  • BLBLI, beta-lactam/beta-lactamase inhibitors; FDA, Food and Drug Administration.