Table 4

Study quality as assessed by CAMARADES risk of bias checklist14

% of included studies
(1) Publication in peer-reviewed journal100
(2) Statement of control of temperature75
(3) Randomisation of treatment or control60
(4) Allocation concealment45
(5) Blinded assessment of outcome75
(6) Avoidance of anaesthetic with marked intrinsic properties90
(7) Use of comorbid animals5
(8) Sample size calculation15
(9) Statement of compliance with regulatory requirements100
(10) Statement regarding possible conflict of interest90
Median study quality (IQR)7 (5–8)