Table 6

Model estimates of an RCR index in 490 ALS studies

VariableLevelORSEP value95% CI
Intercept3.622.340.0471.02 to 12.9
Year200510.0001
20071.020.3970.960.476 to 2.19
20091.330.5020.460.631 to 2.79
20111.940.7280.0770.931 to 4.05
20133.431.410.0031.53 to 7.67
20157.073.16<0.00012.95 to 17.0
Study typeConcept1.370.3690.240.812 to 2.32
CountryAustralia1.311.110.750.250 to 6.85
Belgium2.021.730.410.375 to 10.9
Canada1.711.000.360.545 to 5.38
China0.1990.1110.0040.0671 to 0.592
France0.1710.1090.0060.0489 to 0.599
Germany1.230.7100.720.395 to 3.81
Israel0.7260.5210.660.178 to 2.96
Italy0.2310.09160.0000.106 to 0.503
Japan0.7630.2820.470.369 to 1.58
Other0.3520.1520.0160.151 to 0.821
South Korea0.2410.1340.0100.0810 to 0.716
Spain2.542.760.390.303 to 21.3
Sweden0.9600.8430.960.172 to 5.36
UK0.9710.5540.960.318 to 2.97
USA10.010
Journal Brain 0.2660.2560.170.0406 to 1.75
Brain Res 0.2060.1530.0330.0482 to 0.880
Eur J Neurosci 0.7720.8130.810.0979 to 6.09
Exp Neurol 0.3160.2260.110.0782 to 1.28
Front Cell Neurosci 0.1340.1500.0720.0150 to 1.20
Hum Mol Gen 0.4270.3180.250.0992 to 1.84
J Biol Chem 0.2570.1990.0790.0566 to 1.17
J Neurochem 0.1960.1580.0440.0404 to 0.954
J Neuroinflamm 0.7801.000.850.0632 to 9.63
J Neurosci 0.1190.08790.0040.0279 to 0.506
J Neurosci Res 0.3020.3140.250.0394 to 2.32
Mol Neurodegener 0.1310.1290.0390.0189 to 0.903
Neurobiol Dis 0.2500.1700.0410.0661 to 0.947
Neurosci 1.661.970.670.161 to 17.1
Other0.3680.2040.0710.125 to 1.09
PLOS One 10.41
Proc Natl Acad Sci USA 0.3820.3230.260.0730 to 2.00
SeverityLow00.027
High2.210.7900.0271.10 to 4.45
  • ALS, amyotrophic lateral sclerosis; RCR, Regulatory Compliance Reporting.