Table 5

Model estimates of an MSR index, from the 487 ALS studies that could be used

VariableLevelCoefficientSEP value95% CI
Intercept6.960.572<0.00015.83 to 8.08
Year20050.9810.3870.0110.222 to 1.74
200700.0015
20090.7360.3690.0470.0110 to 1.46
20111.330.355<0.00010.631 to 2.03
20131.490.375<0.00010.748 to 2.22
20151.180.3700.0010.458 to 1.91
Study typePreclinical0<0.0001
Proof-of-concept−2.020.249<0.0001−2.51 to −1.53
CountryAustralia0.1590.6610.81−1.14 to 1.46
Belgium0.5120.6760.45−0.817 to 1.84
Canada−0.1880.4790.70−1.13 to 0.754
China0.2350.5080.64−0.764 to 1.23
France0.2450.6070.69−0.948 to 1.44
Germany1.300.4930.0090.330 to 2.27
Israel−0.2940.5700.61−1.41 to 0.827
Italy1.340.377<0.00010.598 to 2.08
Japan0.3650.3430.29−0.308 to 1.04
Other0.4740.4020.24−0.315 to 1.26
South Korea−0.3070.5290.56−1.35 to 0.733
Spain1.160.6040.055−0.0249 to 2.35
Sweden−0.7980.7560.29−2.28 to 0.688
UK0.6680.5140.19−0.342 to 1.68
USA00.025
Journal Brain −1.590.8590.065−3.27 to 0.100
Brain Res −1.450.6410.024−2.71 to −0.187
Eur J Neurosci −1.120.8680.20−2.83 to 0.581
Exp Neurol −0.9930.5730.084−2.12 to 0.133
Front Cell Neurosci −0.2510.9040.78−2.03 to 1.52
Hum Mol Gen −1.500.5890.011−2.66 to −0.343
J Biol Chem −1.880.662−0.005−3.19 to −0.583
J Neurochem −0.2130.7140.77−1.62 to 1.19
J Neuroinflamm −1.370.8860.12−3.11 to 0.369
J Neurosci −1.050.6170.090−2.26 to 0.163
J Neurosci Res −1.140.8970.20−2.90 to 0.619
Mol Neurodegener 0.00400.9090.99−1.78 to 1.79
Neurobiol Dis −1.530.5330.004−2.58 to −0.481
Neurosci −0.4790.6680.47−1.79 to 0.834
Other−1.110.3850.004−1.86 to −0.348
PLOS One 00.14
Proc Natl Acad Sci USA −1.880.6720.005−3.20 to −0.560
SeverityLow00.80
High−0.07670.3060.80−0.679 to 0.525
  • ALS, amyotrophic lateral sclerosis; MSR, Methodological Standards Reporting.