Model estimates of an MSR index, from the 487 ALS studies that could be used
Variable | Level | Coefficient | SE | P value | 95% CI |
Intercept | – | 6.96 | 0.572 | <0.0001 | 5.83 to 8.08 |
Year | 2005 | 0.981 | 0.387 | 0.011 | 0.222 to 1.74 |
2007 | 0 | – | 0.0015 | – | |
2009 | 0.736 | 0.369 | 0.047 | 0.0110 to 1.46 | |
2011 | 1.33 | 0.355 | <0.0001 | 0.631 to 2.03 | |
2013 | 1.49 | 0.375 | <0.0001 | 0.748 to 2.22 | |
2015 | 1.18 | 0.370 | 0.001 | 0.458 to 1.91 | |
Study type | Preclinical | 0 | – | <0.0001 | – |
Proof-of-concept | −2.02 | 0.249 | <0.0001 | −2.51 to −1.53 | |
Country | Australia | 0.159 | 0.661 | 0.81 | −1.14 to 1.46 |
Belgium | 0.512 | 0.676 | 0.45 | −0.817 to 1.84 | |
Canada | −0.188 | 0.479 | 0.70 | −1.13 to 0.754 | |
China | 0.235 | 0.508 | 0.64 | −0.764 to 1.23 | |
France | 0.245 | 0.607 | 0.69 | −0.948 to 1.44 | |
Germany | 1.30 | 0.493 | 0.009 | 0.330 to 2.27 | |
Israel | −0.294 | 0.570 | 0.61 | −1.41 to 0.827 | |
Italy | 1.34 | 0.377 | <0.0001 | 0.598 to 2.08 | |
Japan | 0.365 | 0.343 | 0.29 | −0.308 to 1.04 | |
Other | 0.474 | 0.402 | 0.24 | −0.315 to 1.26 | |
South Korea | −0.307 | 0.529 | 0.56 | −1.35 to 0.733 | |
Spain | 1.16 | 0.604 | 0.055 | −0.0249 to 2.35 | |
Sweden | −0.798 | 0.756 | 0.29 | −2.28 to 0.688 | |
UK | 0.668 | 0.514 | 0.19 | −0.342 to 1.68 | |
USA | 0 | – | 0.025 | – | |
Journal | Brain | −1.59 | 0.859 | 0.065 | −3.27 to 0.100 |
Brain Res | −1.45 | 0.641 | 0.024 | −2.71 to −0.187 | |
Eur J Neurosci | −1.12 | 0.868 | 0.20 | −2.83 to 0.581 | |
Exp Neurol | −0.993 | 0.573 | 0.084 | −2.12 to 0.133 | |
Front Cell Neurosci | −0.251 | 0.904 | 0.78 | −2.03 to 1.52 | |
Hum Mol Gen | −1.50 | 0.589 | 0.011 | −2.66 to −0.343 | |
J Biol Chem | −1.88 | 0.662 | −0.005 | −3.19 to −0.583 | |
J Neurochem | −0.213 | 0.714 | 0.77 | −1.62 to 1.19 | |
J Neuroinflamm | −1.37 | 0.886 | 0.12 | −3.11 to 0.369 | |
J Neurosci | −1.05 | 0.617 | 0.090 | −2.26 to 0.163 | |
J Neurosci Res | −1.14 | 0.897 | 0.20 | −2.90 to 0.619 | |
Mol Neurodegener | 0.0040 | 0.909 | 0.99 | −1.78 to 1.79 | |
Neurobiol Dis | −1.53 | 0.533 | 0.004 | −2.58 to −0.481 | |
Neurosci | −0.479 | 0.668 | 0.47 | −1.79 to 0.834 | |
Other | −1.11 | 0.385 | 0.004 | −1.86 to −0.348 | |
PLOS One | 0 | – | 0.14 | – | |
Proc Natl Acad Sci USA | −1.88 | 0.672 | 0.005 | −3.20 to −0.560 | |
Severity | Low | 0 | – | 0.80 | – |
High | −0.0767 | 0.306 | 0.80 | −0.679 to 0.525 |
ALS, amyotrophic lateral sclerosis; MSR, Methodological Standards Reporting.