Table 5

Model estimates of an MSR index, from the 487 ALS studies that could be used

Variable	Level	Coefficient	SE	P value	95% CI
Intercept	–	6.96	0.572	<0.0001	5.83 to 8.08
Year	2005	0.981	0.387	0.011	0.222 to 1.74
	2007	0	–	0.0015	–
	2009	0.736	0.369	0.047	0.0110 to 1.46
	2011	1.33	0.355	<0.0001	0.631 to 2.03
	2013	1.49	0.375	<0.0001	0.748 to 2.22
	2015	1.18	0.370	0.001	0.458 to 1.91
Study type	Preclinical	0	–	<0.0001	–
	Proof-of-concept	−2.02	0.249	<0.0001	−2.51 to −1.53
Country	Australia	0.159	0.661	0.81	−1.14 to 1.46
	Belgium	0.512	0.676	0.45	−0.817 to 1.84
	Canada	−0.188	0.479	0.70	−1.13 to 0.754
	China	0.235	0.508	0.64	−0.764 to 1.23
	France	0.245	0.607	0.69	−0.948 to 1.44
	Germany	1.30	0.493	0.009	0.330 to 2.27
	Israel	−0.294	0.570	0.61	−1.41 to 0.827
	Italy	1.34	0.377	<0.0001	0.598 to 2.08
	Japan	0.365	0.343	0.29	−0.308 to 1.04
	Other	0.474	0.402	0.24	−0.315 to 1.26
	South Korea	−0.307	0.529	0.56	−1.35 to 0.733
	Spain	1.16	0.604	0.055	−0.0249 to 2.35
	Sweden	−0.798	0.756	0.29	−2.28 to 0.688
	UK	0.668	0.514	0.19	−0.342 to 1.68
	USA	0	–	0.025	–
Journal	Brain	−1.59	0.859	0.065	−3.27 to 0.100
	Brain Res	−1.45	0.641	0.024	−2.71 to −0.187
	Eur J Neurosci	−1.12	0.868	0.20	−2.83 to 0.581
	Exp Neurol	−0.993	0.573	0.084	−2.12 to 0.133
	Front Cell Neurosci	−0.251	0.904	0.78	−2.03 to 1.52
	Hum Mol Gen	−1.50	0.589	0.011	−2.66 to −0.343
	J Biol Chem	−1.88	0.662	−0.005	−3.19 to −0.583
	J Neurochem	−0.213	0.714	0.77	−1.62 to 1.19
	J Neuroinflamm	−1.37	0.886	0.12	−3.11 to 0.369
	J Neurosci	−1.05	0.617	0.090	−2.26 to 0.163
	J Neurosci Res	−1.14	0.897	0.20	−2.90 to 0.619
	Mol Neurodegener	0.0040	0.909	0.99	−1.78 to 1.79
	Neurobiol Dis	−1.53	0.533	0.004	−2.58 to −0.481
	Neurosci	−0.479	0.668	0.47	−1.79 to 0.834
	Other	−1.11	0.385	0.004	−1.86 to −0.348
	PLOS One	0	–	0.14	–
	Proc Natl Acad Sci USA	−1.88	0.672	0.005	−3.20 to −0.560
Severity	Low	0	–	0.80	–
	High	−0.0767	0.306	0.80	−0.679 to 0.525

ALS, amyotrophic lateral sclerosis; MSR, Methodological Standards Reporting.