eLetters

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  • And what about in silico stroke models?

    Dear Pandora and Rebecca,We were quite interested by your paper "Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? An analysis of opinion papers" (BMJ Open Science, 2020). Thank for this illuminating work which makes concrete what we had in mind since a work published in 2004-2007 (Dronne MA, Boissel JP, Grenier E, Gilquin H, Cucherat M, Hommel M, Barbier E, Bricca G. Mathematical modelling of an ischemic stroke: an integrative approach. Acta Biotheor. 2004;52:255-72; Dronne M.A., Boissel J.P., Grenier E., A mathematical model of ion movements in grey matter during a stroke. J Theor Biol 2006;240:599-615; 247. Dronne MA, Grenier E, Dumont T, Hommel M, Boissel JP. Role of astrocytes in grey matter during stroke: A modelling approach. Brain Res. 2007;1138:231-42; 252. Dronne MA, Grenier E, Chapuisat G, Hommel M, Boissel JP. A modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients. Prog Biophys Mol Biol. 2008. Grenier E, Dronne MA, Descombes S, Gilquin H, Jaillard A, Hommel M, Boissel JP. A numerical study of the blocking of migraine by Rolando sulcus. Prog Biophys Mol Biol. 2008). At this time there were circa 300 "neuroprotective" agents that had worked on rodent models and failed when tested in stroke patients. We used a mathematical model of acute stroke with a rodent and a human versions. Our simulations showed that drugs reducing...

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