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Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis
  1. Dereje Nigussie1,2,
  2. Belete Adefris Legesse1,
  3. Gail Davey2,3,
  4. Abebaw Fekadu1,2,
  5. Eyasu Makonnen1,4
  1. 1Addis Ababa University, College of Health Sciences, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), P.O. Box: 9086, Addis Ababa, Ethiopia, Addis Ababa, Ethiopia
  2. 2Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, UK, Brighton, UK
  3. 3School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia
  4. 4Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
  1. Correspondence to Mr Dereje Nigussie; D.Woldemichael{at}


Objectives Medicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities.

Methods and analysis The guidance of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) statement will be used. This review will consider all controlled studies of anti-inflammatory and wound healing properties (both in vivo and in vitro) and in vitro anti-infective properties of medicinal plants found in Ethiopia. Data sources will be EMBASE, PubMed/Medline, Scopus and Google Scholar. Guidance documents on good in vitro methods and checklists for reporting in vitro studies will be used for quality assessment of in vitro studies. The risk of bias tool for animal intervention studies (the SYRCLE RoB tool) will be used to assess the validity of studies. The main outcomes will be percent inhibition of inflammation, time of epithelisation and tissue tensile strength in wounds and microbial growth inhibition.

Ethics and dissemination The findings of this systematic review will be disseminated by publishing in a peer-reviewed journal and via conference presentations. Ethical clearance was obtained from the Brighton and Sussex Medical School, Research Governance & Ethics Committee (RGEC) and Addis Ababa University, College of Health Science, Institutional Review Board.

PROSPERO registration number This systematic literature review has been registered with PROSPERO (registration number CRD42019127471).

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:

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  • Contributors Conception and design: DN, GD, EM, BAL and AF. Data analysis and interpretation: DN, GD, EM and BAL. Manuscript writing: DN. Manuscript editing: DN, GD, EM, BAL and AF.

  • Funding This work was supported by the National Institute for Health Research (NIHR) Global Health Research Unit on NTDs at Brighton and Sussex Medical School using Official Development Assistance (ODA) funding. The views expressed here are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

  • Competing interests None declared.

  • Ethics approval Not applicable

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Preregistration Study design has been preregistered and is publicly available at, ID: PCTE0000104.

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