Responses

Download PDFPDF

Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? An analysis of opinion papers
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

PLEASE NOTE:

  • Responses are moderated before posting and publication is at the absolute discretion of BMJ, however they are not peer-reviewed
  • Once published, you will not have the right to remove or edit your response. Removal or editing of responses is at BMJ's absolute discretion
  • If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms]
  • By submitting this response you are agreeing to our full [Response terms and requirements]

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    And what about in silico stroke models?

    Dear Pandora and Rebecca,We were quite interested by your paper "Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? An analysis of opinion papers" (BMJ Open Science, 2020). Thank for this illuminating work which makes concrete what we had in mind since a work published in 2004-2007 (Dronne MA, Boissel JP, Grenier E, Gilquin H, Cucherat M, Hommel M, Barbier E, Bricca G. Mathematical modelling of an ischemic stroke: an integrative approach. Acta Biotheor. 2004;52:255-72; Dronne M.A., Boissel J.P., Grenier E., A mathematical model of ion movements in grey matter during a stroke. J Theor Biol 2006;240:599-615; 247. Dronne MA, Grenier E, Dumont T, Hommel M, Boissel JP. Role of astrocytes in grey matter during stroke: A modelling approach. Brain Res. 2007;1138:231-42; 252. Dronne MA, Grenier E, Chapuisat G, Hommel M, Boissel JP. A modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients. Prog Biophys Mol Biol. 2008. Grenier E, Dronne MA, Descombes S, Gilquin H, Jaillard A, Hommel M, Boissel JP. A numerical study of the blocking of migraine by Rolando sulcus. Prog Biophys Mol Biol. 2008). At this time there were circa 300 "neuroprotective" agents that had worked on rodent models and failed when tested in stroke patients. We used a mathematical model of acute stroke with a rodent and a human versions. Our simulations showed that drugs reducing...

    Show More
    Conflict of Interest:
    Novadiscovery is developing mathematical models of diseases, including stroke